Aerocort inhaler is used as an anti-asthmatic drug for the treatment of asthma including wheezing and shortness of breath. It works by relaxing the air passage muscles which results in easy breathing. It is a combination of two drugs that are Levosalbutamol and Beclomethasone dipropionate.
Mechanism
As it contains two drugs, I will discuss both of them separately.
- Levosalbutamol: It acts as beta 2 adrenergic agonist working as a bronchodilator for treating asthma and also as uterine relaxant to avoid premature labour pain.
This drug acts as a beta 2 receptor stimulation, which then further increases cAMP responsible for the formation of bronchial muscle cells and thereby causing relaxation.
This cAMP in mast cells and inflammatory cells helps in decreasing mediator release. It helps in reversible airway obstruction and thus resulting in widening of bronchioles, but one should ask a physician if one has hypertension, ischaemic disease, or taking digitalis injections.
These are the fastest working bronchodilators with minimal side effects. It is taken by inhaling the drug mostly given through pressurized metered doses which dilates bronchioles within 5 min and its actions lasts for around 2-4 hours. It is used to terminate attack of asthma. - Beclomethasone: It is actually not a bronchodilator but a drug of class glucocorticoids which works by inhibiting inflammatory cytokine production and also eosinophilic, lymphocytic infiltration of drugs.
They actually work by reducing bronchial hyper reactivity, mucosal oedema, and also inhibits antigen antibody reaction. It provides sustained sympathomimetic relief by improving airflow, reducing asthma exacerbations, and resisting disease progression. They also provide with smooth muscle responsiveness towards beta 2 agonists.
Thus, the combination of these two drugs belonging from different classes helps in providing a comprehensive treatment approach for managing respiratory conditions.
It helps in dealing both the problems associated with asthma problems i.e. inflammatory problem is treated by beclomethasone and constricted bronchioles are treated by levosalbutamol.
This dual action Aerocort helps in stabilizing the ample situations related to respiratory illness such as patients requiring maintenance therapy and also for patients experiencing acute attacks.
Overview
Overview Aerocort Inhaler
Uses
Uses Aerocort Inhaler
Firstly check the label for directions before use.
- Shake the inhaler
- Keep it in mouth, press down one time for release of medication and hold the breath for 10 seconds
- Repeat until you achieve the target of puffs suggested by the doctor.
- Then rinse the mouse thoroughly to avoid irritation and dryness
These are the conditions which are not controlled by bronchodilators itself and with patients having recurrent episodes of asthmatic attacks.
The patient is started with inhaled corticosteroids along with bronchodilators.
- Management of asthma: It is usually prescribed for maintaining long-term asthma problem
- COPD (chronic obstructive pulmonary disease): In this situation, it helps to treat inflammation and prevent exacerbations. Also enhancing the compliance and managing all disease.
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Drug Cost
Drug Cost in India
Benefits and Side-effects
Side-effects of Aerocort Inhaler
- Throat irritation
- Coughing
- Hoarseness
- Dysphonia
- Oropharyngeal candidiasis
- Fungal infection
- Headache
- Muscle cramp
- Pharyngitis
- Dizziness
- Vomiting
- Dryness of mouth
- Bronchitis
- Nausea
- Thrush
- GIT motility disorder
Long term effects include
- Mood changes
- Osteoporosis
- Growth retardation
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Composition
Composition of Aerocort Inhaler
- Levosalbutamol tartrate IP 50mg
- Beclomethasone dipropionate 50mg
- Absolute alcohol content 7.4%
- Suspended in propellent HFA 134a..qs
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Substitute
Substitute
Safety Advice
Safety Advice of Aerocort Inhaler
- Avoid use alcohol as it may cause drowsiness
- Unsafe during pregnancy
- Safe during breastfeeding
- No interaction while driving
- No effect on kidney
- No effect on liver function
- Inhalation only, not to swallow
- Take it on same time to maintain consistency
- Do not work on the spot so may not help in relieving sudden attack
- Gargles after every inhalation to avoid fungal infections
- Start under medical supervision
- Regular monitoring of blood potassium levels in blood, as it may cause hypoxia
- Do not stop suddenly might cause recurrence of breathing problems
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