Aciloc 150 Tablet

Aciloc tablets contain “Ranitidine” as an active ingredient to treat problems like peptic ulcers, gastric ulcers, and most importantly gastroesophageal reflux disease (GERD).

They work by reducing the production of acid produced in our stomach. It comes under the category of first class highly effective drug for treatment of acid-peptic disease. It acts by blocking H2 receptors which are involved in production of acid.

The gastric acid is produced by gastric parietal cells located in gastric glands found in the lining of the fundus and body regions of the stomach. To activate these cells, proton pump H⁺K⁺ATPase enzyme comes into action which is further activated by H2 receptors.

When we ingest food, this food interacts with and activates gastrin in G cells of the stomach. This gastrin causes CCK2 to work up and release histamine is responsible for activating H2 receptors which will now activate this proton pump by releasing Ca2⁺ ions by generating CAMP.

Thus, this cycle works by release of gastric acid through a proton pump. 

Now, how does ranitidine work? This drug acts by blocking the activation H2 receptors which will not further activate proton pump and thus inhibiting the release of gastric acid causing problems of peptic ulcer, gastric, GERD.

Drug Interactions

• Efavirenz (life-threatening effect)
• Efcure (life-threatening effect)
• Efamat (life-threatening effect)
• Effahope (life-threatening effect)
• Nevimune  (life-threatening effect)
• Nevirapine (life-threatening effect)
• Acarbose  (serious interaction)
• Atazanavir (serious interaction)

H2 blockade

This drug causes blockage of histamine induced gastric release, cardiac stimulation, uterine relaxation and even bronchial relaxation. They are competitive antagonists of cells releasing histamine. 

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Gastric ulcers

It helps in suppression of gastric release at all phases i.e. basal, psychic, neurogenic, and gastric. These phases are inhibited depending on the dose amount, but more impact occurs in the basal effect.

It has an impact on all other stimuli as well that are acetylcholine, gastrin, insulin, alcohol, as well as food. It affects 60-70 % reduced volume secretion of gastric juice, pepsin content within 24 hrs.

It also prevents the effect of gastric juice which occurs due to stress and drugs like NSAIDs and many other drugs without impacting the absorption of vitamin B12.

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GERD

It helps by decreasing the acidity of gastric juice released but not wholly acid suppression with increase in pH more than 4 for less than 8 hrs in 24 hrs duration.

Only in mild cases, adequate symptom relief occurs. These are considered ‘on demand’ symptom relief for occasional and stage 1 GERD. One can find relief in 30-60 min after intake of drugs.

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Peptic ulcers

It helps in treating 60-80% of duodenal ulcers healing in 4 weeks of treatment initiation and healing increases to about 80-90% in further 8 weeks.

Should be taken at night with a single daily dose for efficacy and also reduces relapse rate. 

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Non ulcer dyspepsia

Used for treatment of epigastric pain or heartburn characterized by abdominal fullness,nausea, bloating, gas, pain, and early satiety.

• Bleeding from stress ulcers and erosive gastritis
• Urticaria
• Prophylaxis of aspiration pneumonia

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Benefits

Positive impacts of Ranitidine

• Longer duration action for acid suppression for at least 24 hrs.
• Highly potent.
• No anti androgenic effect.
• No increase in prolactin secretion or estradiol.
• No effect on male sex functions or gynaecomastia.
• Little effects outside GIT system.
• Less permeability into brain.
• Less liver metabolism inhibition.
• Lower side effects incidence.\

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Side effects

Adverse effects

• Headache
• Diarrhoea
• Constipation
• Dizziness
• GIT problems
• Stomach pain

These are mild effects which vanish away by adjusting the dose or by withdrawal. Consult a doctor before proceeding for any step.

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Ranitidine hydrochloride IP         167.4 mg 

               OR

Ranitidine                                      150 mg

Colours: Tartrazine, Briliant blue CSF, Titanium dioxide IP

You should also know – Limcee tablet uses

• Avoid use of alcohol 
• It is safe in pregnancy
• Safe for breastfeeding mothers
• Does not affect ability to drive
• Cautious use in kidney problems. One should consult a doctor before taking medicine.
• Also in liver problems, consult physician for dose adjustment
• Avoid citrus fruits, (orange, lemon) which increase acid in the stomach.
• Take medicine at least 30-60 min before having food.
• Inform doctor if facing any issues with Aciloc 150.
• Do not take medicine without doctor consultation and also do not stop medication without doctor consultation.

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