Acenac-P Tablet is the pain-relieving medicine which helps in alleviating inflammatory pain related to various medical problems related to joints and bone such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis, and also helps to relieve muscle pain, back pain, toothache, and even ear and throat pain.
It has a combination of paracetamol and aceclofenac. It comes under Schedule H drugs which means it cannot be purchased without a proper physician’s prescription.
Paracetamol
It is the active metabolite of phenacetin. Phenacetin is an inactive form but when metabolized by de-ethylation it gets active and that form is known as paracetamol. This active metabolite paracetamol works by increasing pain threshold with its weak peripheral anti-inflammatory element.
It has additive analgesic action with its spontaneous antipyretic that means treating fever as well as pain in one dose.
Paracetamol has negligible anti-inflammatory action has weak inhibitor of PG synthesis in peripheral tissues, but is more active on COX 1 or COX 2 in the brain.
It is unable to inhibit COX in the presence of peroxides which are generated at sites of inflammation which opens divergence in its analgesic, antipyretic and anti-inflammatory properties, as peroxides are actually not present in the brain, so is no effective at that site.
The ability of paracetamol to inhibit COX-3 also accounts for its analgesic-antipyretic action. It acts as antipyretic by inhibiting the release or synthesis of Prostaglandin (PG) hormone which is actually released by pyrogen causing increase in body temperature.
Aceclofenac
It inhibits prostaglandin (PG) synthesis and is preferentially COX-2 inhibitors instead of COX 1, that is why it is more effective with less side effects to stomach problems.
It works by stopping the impacts of cyclooxygenase (COX) proteins, which deliver prostaglandins causing irritation and agony flagging.
Aceclofenac binds with enzymes and undergo chemical reactions like oxidative digestion converting to hydroxy metabolites as well as formation to glucuronic corrosive, sulfate, and taurine.
The essential metabolite of aceclofenac which has pain reliving property is 4′- hydroxy diclofenac which is formed by CYP2C9 enzyme after binding with aceclofenac and number of reactions.
Overview
Overview Acenac-P Tablet
Uses
Uses Acenac-P Tablet
Ankylosing spondylitis
Ankylosing spondylitis is a sort of joint pain that principally influences the spine and makes a portion of the little bones combine.
Ankylosing spondylitis-related stiffness and pain, which includes lower back pain, hip pain, and even pelvis pain, are treated with the help of Acenac-P Tablet.
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Osteoarthritis
It is the degenerative joint condition as well as affecting surrounding tissues which results in pain, swelling, stiffness and thus a person is unable to move freely.
Alongside Acenac-P, improve eating habits and workouts which helps in relieving pain.
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Rheumatoid arthritis
It is the auto-immune disease which causes severe damage to the joints around the whole body. It not only affects joints but also impacts other body systems like skin, eyes, lungs, heart and even blood vessels.
This medication helps to get relief from daily pain interrupting with daily activities.
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Mild sciatica pain
It can be defined as the main radiating from back and going towards leg downwards. The situation makes difficult for person even to move or stand straight.
For mild pain, this medication can be effective but other than this consult physician, perform yoga regularly and also avoid strenuous exercises.
- Muscle pain
- Back pain
- Toothache
- Ear pain
- Throat pain
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Drug Cost
Drug Cost in India
Benefits and Side-effects
Side-effects of Acenac-P Tablet
Side effects
- Nausea
- indigestion
- increased liver enzymes
- dizziness
- drowsiness
- Loss of appetite
- diarrhoea
- Fever
- Vomiting
- Allergic skin reaction
- Mouth sores
- stomach pain
- Bloody and cloudy urine
- Stomach irritation
- Fatigue
- heartburn
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Composition
Composition of Acenac-P Tablet
Aceclofenac I.P ……………….100mg.
Paracetamol I.P……………….350mg.
Excipients………………………q.s.
Colour…………………………. Titanium dioxide.
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Substitute
Substitute
Safety Advice
Safety Advice of Acenac-P tablet
- The drug has to be taken with food to avoid stomach problems like stomach upset, gastric ulcers.
- The drug has to be taken with water. It is not advisable to crush, or take it by any other means.
- It is not suitable for everyone so everytime consult a physician before taking this drug.
- Avoid taking this medication with any other drugs containing paracetamol as an active ingredient as it may cause paracetamol toxicity.
- It may cause dizziness or sleepiness, so avoid driving after taking this medication.
- To avoid risk of liver damage, avoid consuming alcohol with it as it might even increase risk of drowsiness.
- As this medication has increased risk of stomach ulcers, it is better to inform the physician about the history of stomach ulcers if they have any.
- It might not be safe during pregnancy, so better to avoid and if needed in an emergency case consult a doctor.
- Better to have physiotherapy along with these medications for better relief from muscle pain as it will help more relaxation of pain rather than avoiding pain sensations by consuming medications.
- In case you have missed the dose and time has arrived for another dose, so avoid missed doses but do not consume double dose as it might cause toxicity in liver which increases risk of liver damage.
- Inform physician if you have liver disease as it is not recommended by physicians in chronic liver disease or liver infections.
- Also, there is always a requirement to adjust dose in kidney problem patients as it has an effect on kidney function. So, inform the physician if you had any history of kidney infection or are currently suffering from it.
- There is no document or research available regarding the effect of this medication on breastfeeding. So better to consult a physician about this.
- Avoid consuming fatty or fried or junk foods with this medication to avoid nausea and vomiting like side-effects.
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